Among vaccine adjuvants, the most widely used is alum, derived from aluminum hydroxide or phosphate. The neurotoxicity of aluminum was denounced more than 100 years ago. Scientists assume that the damage caused by aluminum in the heart of cells is related to the production of free radicals, disturbances in glucose metabolism and disruption of nerve impulses. Vaccine adjuvants that contain aluminum and mercury increase the effects of this neurotoxicity.

The latest generations of vaccines contain only one part of the disease germ, as opposed to the old vaccines that contained the whole germ. This element alone is no longer able to provoke a sufficient immune response. Therefore, this immune response must be reinforced with "improved" and more potent adjuvants.

Since 1993, it has been known that Hepatitis B, Hepatitis A and Tetanus vaccines contain aluminum and can be the cause of "new" diseases, such as macrophage myofasciitis, chronic fatigue, fibromyalgia, and muscular or neurological pain.

One of the most effective adjuvants is the oil-based one, but it has always been considered too reactive for humans and therefore its use is reserved for animal experiments.

The use of the adjuvant called "Freund's adjuvant " (water and oil emulsion, sometimes with killed Koch's bacilli added, it is then called "Freund's complete adjuvant") is also normally prohibited in humans because of its toxicity and strong inflammatory reactions. It is used for veterinary experiments, and depending on the location of the injection, it causes severe tissue damage accompanied by severe pain.

Oil-based adjuvants have the ability to activate the immune system and elicit an extremely powerful response creating a kind of immune system chaos. The latter, totally out of control, starts to attack elements that it is supposed to ignore in normal times.

Another theory is based on the "programmed" immune response. In fact, over time it has acquired an intelligence that allows it to fight precisely everything it considers a threat to the organism, but not the molecules that make up the structures and tissues of our body. Our bodies have a number of oil and lipid molecules that are similar in structure to the molecules in oil-based additives. When these adjuvants are injected, what specialists call a cross-reaction occurs, i.e. the immune system destroys all the oil molecules, both those of the body and those of the adjuvant. This process is the cause of the demyelination involved in multiple sclerosis.